Ryan K. Orosco, MD, FACS

About

Surgery is the oldest cancer treatment — and the least quantified. I'm an engineer who became a cancer surgeon to change that.

I trained in electrical engineering before medical school, and I've spent my career bringing measurement, robotics, and now AI into the operating room — the place in cancer care where the stakes are highest and the data is thinnest.

The problem that drives me is simple to state. When my group analyzed 6.5 million cancer operations nationally, oral cavity cancer had the highest positive-margin rate of any major cancer affecting both men and women — meaning too many operations still leave tumor behind, with real consequences for patients. Better information at the point of surgery means better decisions, and better decisions mean better outcomes.

That conviction has taken me from the fluorescence-guided surgery lineage of Nobel laureate Roger Tsien to serving as national and site PI on all three pivotal trials of intraoperative fluorescence-guided nerve visualization — the Phase 1/2 study and both Phase 3 trials, completed in 2025, with the Phase 1 results published in Nature Communications. My translational robotics work with engineering collaborators spans tissue modeling, deformable navigation, and surgical AI, with 110 publications across medicine and engineering journals.

Clinically, I'm a head and neck surgical oncologist and microvascular reconstructive surgeon at the University of New Mexico, my home state, where I serve as Associate Professor with Tenure, care for patients with complex head and neck tumors, and train the next generation of surgeon-scientists.

The through-line in everything: every surgery is a data-generation event. The future of surgical oncology is quantitative — and I intend to help build it.

(Also: I grow agave.)

Download CV (PDF)

Clinical practice

Fellowship-trained head & neck surgical oncology and microvascular reconstruction at the University of New Mexico Comprehensive Cancer Center.

Dr. Orosco cares for patients with the full range of head and neck cancers, thyroid and parathyroid disease, salivary gland disorders, and complex facial trauma, pairing advanced surgical techniques — including robotic and fluorescence-guided approaches — with reconstruction that preserves function and quality of life.

As Director of Oral & Maxillofacial Surgery, he leads UNM's OMFS program and has built multidisciplinary clinical initiatives that expand access to complex oncologic, reconstructive, and facial trauma care across New Mexico.

Areas of practice

Head & neck surgical oncology
Oral cavity, oropharyngeal, thyroid, salivary gland & skin cancers
Microvascular free-flap reconstruction
Oral & maxillofacial surgery
Maxillofacial trauma
Thyroid & parathyroid surgery
Robotic head & neck surgery
Fluorescence-guided surgery & molecular imaging

Seeing patients

UNM Comprehensive Cancer Center — Head & Neck Cancers
Clinical office: 2211 Lomas Blvd NE, MSC10 5610, Albuquerque, NM 87131
Four research areas converging on precision surgical oncology — quantitative imaging and AI-assisted surgical guidance: clinical outcomes and head & neck oncology (75 publications, since 2010), robotics and intelligent systems (23, since 2017), fluorescence and molecular imaging (9, since 2013), pathology and molecular data (3, since 2014).

Publications

All 110 published works, grouped by year and filterable by research area. Titles link to PubMed; select an author list to expand it. Sourced from my curriculum vitae, September 2026.

No publications match that search.

Book chapters

6 chapters
  1. Mandibulotomy (Ch 10) & Segmental and Marginal Mandibulectomy (Ch 11). Orosco RK & Chang S. Surgical Techniques in Otolaryngology – Head & Neck Surgery. Jaypee Brothers Medical Publishers, 2016.
  2. Management of the Salvage Laryngectomy Defect and Complications. Orosco RK & Rosenthal EL. Open Access Atlas of Otolaryngology, Head & Neck Operative Surgery. University of Cape Town, 2016.
  3. Facial Pain Syndromes. Orosco R & Coffey C. Gland Preserving Surgery — A Problem-Based Approach. Springer, 2018.
  4. Oropharyngeal Cancer: Contemporary Management. Tam K, Saraswathula A, Holsinger FC, Orosco RK. Otolaryngology – Head and Neck Surgery: Principles & Practice. Jaypee Brothers Medical Publishers, 2018.
  5. Physics and Principles of Ultrasound. Orosco RK, Orloff LA. Ultrasonography of the Head and Neck. Springer, 2019.
  6. Non-Neoplastic Salivary Gland Disease; Embryology and Anatomy of the Salivary Glands; Malignant Salivary Gland Tumors; Benign Salivary Gland Neoplasms. Goldenberg: Handbook of Otolaryngology: Head and Neck Surgery, 3rd ed. Elsevier, 2023.

Clinical trials & funding

National and site principal investigator on all three pivotal trials of intraoperative fluorescence-guided nerve visualization, with peer-reviewed extramural, federal, and institutional support.

Pivotal clinical trials

3 trials · national & site PI
Phase 1/2 · completed Aug 2021

ALM-488 to highlight nerves in head & neck surgery

First-in-human evaluation of the fluorescent nerve-imaging agent bevonescein — published in Nature Communications, 2025.

NCT04420689
Phase 3 · completed Nov 2025

ALM-488 for intra-operative visualization of nerves

Pivotal multicenter study of nerve visualization in head & neck surgery.

NCT05377554
Phase 3 · completed Nov 2025

Bevonescein for intra-operative nerve visualization

Second pivotal multicenter study in head & neck surgery.

NCT06227585

Grant & contract funding

9 awards
2021–22
American Cancer Society pilot grant — tissue modeling in transoral robotic cancer surgery
Principal investigator
2021–22
UC San Diego ACTRI SUSTAIN award — translational robotic surgery research
Principal investigator
2020
UC San Diego Academic Senate bridge funding — motion scaling & augmented reality for time-delayed robotic surgery
Principal investigator
2018
UC San Diego ACTRI Galvanizing Engineering in Medicine — telerobotic surgery accuracy, efficiency & safety
Co-PI, with M. Yip
2018
UC San Diego Head & Neck Research Committee grant — dysphagia home exercise program adherence & outcomes
Co-investigator
2017
U.S. Army USAMRMC / TATRC Rapid Innovation Fund — telemedicine & advanced surgical technology
Site co-investigator
2024
UNM Comprehensive Cancer Center pilot — molecular mechanisms of 3q amplification in HNSCC metastasis (awarded; deferred)
PI, with A. Sahu & V. Palanisamy
2012–13
NIH / NIDCD T32 Kirschstein research training award — fluorescence-guided surgery, mentor Q. Nguyen
Trainee
2007
NIH T32 predoctoral clinical research training program, Johns Hopkins — advisor N. Powe
Trainee

Experience & education

Academic appointments, leadership roles, and training — from electrical engineering at New Mexico State to tenured faculty at the University of New Mexico.

Leadership & administrative roles

4 entries
2025–present
Medical Director, Oromaxillofacial Service Line
University of New Mexico Hospital
2022
Disease Team Leader, Head & Neck Oncology (elected)
UC San Diego Moores Cancer Center
2026
AAO-HNSF Physician Leadership Institute
Led by WittKieffer
2026
Kerecis
Key Opinion Leader

Academic appointments

8 entries
2026–present
Associate Professor with Tenure, Department of Surgery
Division of Otolaryngology, University of New Mexico — Head & Neck Surgical Oncology & Microvascular Reconstruction; Director, Oral & Maxillofacial Surgery
2023–2026
Associate Professor, tenure track
Department of Surgery, University of New Mexico
2023–present
Medical staff
Presbyterian Hospital, Albuquerque, NM
2022
Assistant Professor
Department of Surgery (Otolaryngology), University of New Mexico
2017–2022
Assistant Professor
Department of Surgery (Otolaryngology), UC San Diego
2018–2022
Affiliate Professor
Department of Electrical & Computer Engineering, UC San Diego
2017–2022
Research Health Science Specialist (WOC)
VA San Diego Healthcare System
2016–2017
Clinical Instructor
Department of Otolaryngology, Stanford School of Medicine

Education & training

5 entries
2016–2017
Fellowship — Head & Neck Surgical Oncology and Microvascular Reconstruction
Stanford University
2011–2016
Residency — Otolaryngology, Head & Neck Surgery
UC San Diego
2010–2011
Internship — General Surgery (Otolaryngology)
UC San Diego
2006–2010
Doctor of Medicine
Johns Hopkins School of Medicine, Baltimore, MD
2002–2006
BS, Electrical Engineering, High Honors
Klipsch School of Electrical & Computer Engineering, New Mexico State University — minors in mathematics and biochemistry

Certification & licensure

3 entries
2017–present
Diplomate, American Board of Otolaryngology
2016
Thyroid & Parathyroid Ultrasound, Verification Level III
American College of Surgeons
Current
Licensed physician — New Mexico and Nevada

Talks & teaching

Invited lectures and panels across four continents, plus course leadership, resident education, and mentorship at every training stage. From my curriculum vitae, September 2026.

Invited lectures & presentations

50+ talks
International 8 talks
  • Precision optical intraoperative guidance for head & neck surgery, and Phase 3 pivotal data for fluorescence-enabled intraoperative nerve identification — panel & podium presentations. AHNS 2026 International Conference, July 2026.
  • Intraoperative nerve-specific fluorescence imaging — panelist & proffered-papers moderator. 11th International Conference on Head & Neck Cancer, Montréal, Canada, July 2023.
  • Technological developments and translational research in robotic surgery — lecture, session moderator & panelist. 4th European Head & Neck Society Robotic Conference, Paris, France, Dec 2021.
  • Telerobotics and semiautomated robots in medicine. 3rd EHNS Workshop on Robotic Surgery in Head & Neck, London, England, Nov 2019.
  • Semi-autonomy in robotic surgical systems. International Congress of ORL-HNS, Seoul, Korea, April 2019.
  • The frontline of head & neck surgery practice in the US. Yokohama City University Otolaryngology Grand Rounds, Yokohama, Japan, April 2019.
  • Color-coded surgery. 4th Annual International Medical Students Meeting, Lisbon, Portugal, March 2013.
Regional & national 11 talks
  • Futuristic robotic surgery. San Diego Chapter, American College of Surgeons, April 2024.
  • Immediate jaw reconstruction — course faculty. KLS Martin course, San Diego, CA, March 2024.
  • Oropharynx cases — panelist. Vanderbilt Fall CME Meeting, Nashville, TN, Sept 2023.
  • Mouth lesions. New Mexico Medical Society Noon Zoom, Feb 2023.
  • Shared decision-making between the MD and SLP in head & neck cancer care. ASHA Annual Conference, Nov 2022.
  • Nerve-specific dyes — normal tissue identification. Penn Medicine Precision Surgery Intraoperative Molecular Imaging, 3rd Clinical Trials Update, Nov 2022.
  • Imaging and robotic innovations — Karl Horn Lectureship. 7th Annual Balloon Fiesta Otolaryngology Symposium, New Mexico Society of Otolaryngology, Sept 2022.
  • Head & neck cases — panelist. Cedars-Sinai Eerie ENT Conference, Los Angeles, CA — 2018, 2019 & 2020.
  • Essentials practice webinar: head & neck reconstruction. American Academy of Facial Plastic Surgery, COSM, June 2020.
  • Saving the warrior: semiautonomous telesurgical robots in combat casualty care. Stanford Medicine X Conference, Sept 2017.
Local & institutional 35+ talks
  • Head & neck reconstruction. New Mexico State Assembly of the Association of Surgical Technologists, Albuquerque, March 2025; Albuquerque VA Otolaryngology Grand Rounds, April 2024.
  • Larynx reconstruction & partial laryngectomy; neck dissection. UNM Otolaryngology Resident Didactics, Sept 2023.
  • Basics of otolaryngology. UNM Surgery Clerkship lectures, 2023 (four sessions).
  • Maximizing function after head & neck reconstruction. UNM Speech Pathology Conference, Jan 2023.
  • Tracheostomy & laryngectomy tubes. UCSD Jacobs Medical Center Nursing Lecture, Aug 2022.
  • TORS navigation. UC Irvine Otolaryngology Grand Rounds, April 2022.
  • Advanced head & neck reconstruction. UCSD Radiology Grand Rounds, April 2022.
  • Fluorescence-guided surgery — nerve imaging. Moores Cancer Center Solid Tumor Therapeutics Retreat, Nov 2021.
  • From manuscripts to grants; head & neck boards and tumor boards; pushing the robotic surgery envelope; next-generation and futuristic robotics; mandible reconstruction; free-flap monitoring and care pathways; oral cavity and osseocutaneous forearm reconstruction; sentinel lymph node biopsy for melanoma; and additional teaching conferences and grand rounds. UC San Diego & Rady Children's, 2017–2021.
  • Remote robotic surgery and reconstruction. UCSD Plastic Surgery Grand Rounds, April 2020.
  • Head & neck cancer. UCSD General Internal Medicine Grand Rounds, Sept 2019.
  • Stanford medical student head & neck lectures. 2016–2017.
  • Earlier resident and grand-rounds lectures on surgical salvage, molecular prognostic models, biomarkers & targeted therapies, facial reanimation, lateral pharyngotomy, and outcomes research. UC San Diego & Johns Hopkins, 2009–2016.

Course leadership & teaching

6 entries
2024–2026
Organizing & Scientific Review Committee, SANDIA research symposium
UNM Department of Surgery, 2025 & 2026; organizing committee, 10th Annual UNM Surgery & Ophthalmology Research Symposium, 2024
2024–2025
Course co-chair, Balloon Fiesta Otolaryngology Symposium
9th (2024) and 10th (2025) annual symposia, New Mexico
2023–2025
UNM teaching
Surgery clerkship lectures & suturing workshop; annual hands-on airway course (Anesthesiology, 2023–2025); hands-on courses for residents in fibula free-flap mandible reconstruction and transoral robotic surgery; career-exploration lectures
2020–2023
Course co-director & faculty, Southwest Region Otolaryngology Emergencies Boot Camp
UC San Diego — co-director 2020–2022, faculty 2023
2018–2022
Course director, UCSD SURG 433 — Sub-Internship in Otolaryngology
Plus faculty roles across UCSD surgery courses, resident boot camps (led 2018–2020), anatomy lab proctoring, and thyroid ultrasound training
2017–2018
Program director & course faculty
Multidisciplinary Head & Neck Cancer Care in the Era of Innovation (UCSD, 2018); Bay Area Neck Dissection & Free Flap Course (Stanford, 2017); ACS thyroid/neck ultrasound instructor; microvascular and FEES course faculty

Mentoring

Faculty · residents · students
Faculty
UNM Department of Surgery IMPACT Faculty Mentorship Program, 2025–2026
Mentees: Erin Howell, MD (trauma surgery) and Liat Shama, MD (rhinology), both Assistant Professors at UNM
Residents
Otolaryngology resident mentees
Quinton Blount, Ashley Dorneden (H&N fellowship, Johns Hopkins), Antoinette Esce (fellowships at Mt. Sinai and Memorial Sloan Kettering), Aurora Maes, Kris Merrill, Allison Price (H&N fellowship, Toronto)
Students
Medical & undergraduate mentees
Luis Martinez (UNM SOM — matched in Otolaryngology, University of Arizona); Neil Mahto (Johns Hopkins, biomedical engineering); faculty mentor, UCSD Health Professions Mentorship Program; earlier peer advising at Johns Hopkins and Incentive Mentoring Program, Baltimore

Honors & service

Professional recognition, society leadership, and service to the field.

Recognition & honors

12 entries
2022
Elected Disease Team Leader, Head & Neck Oncology
UCSD Moores Cancer Center
2022
Whitehill Award, UCSD Academy of Clinician Scholars
Otolaryngology
2022
Teacher of the Year
UCSD Division of Plastic Surgery
2021
San Diego's Top Doctors list
2021
Best Paper nomination
IEEE International Conference on Robotics and Automation (ICRA)
2020
UCSD Otolaryngology Teaching Award
2018–20
UCSD Hispanic Center of Excellence Faculty Development Program
2017
Fellow of the Year Teaching Award
Stanford Otolaryngology
2016
Highest in-service exam score
UC San Diego Otolaryngology
2015
Poster Award, American Head & Neck Society
2014
American Thyroid Association Trainees' Grant
2001–06
Eagle Scout; Tau Beta Pi & Alpha Chi honor societies
Dominico Marquez Leadership Award, St. Pius X High School

Professional societies

7 entries
2023–present
New Mexico Medical Society
Vice Presiding Officer (2024–26); AMA Young Physician Section delegate (2023–24); CME Committee (2023–26)
2013–present
American Head & Neck Society
2014–present
American College of Surgeons, Associate Fellow
New Mexico Chapter (2023–present); San Diego Chapter (2019–22)
2014–present
Triological Society
2010–present
American Academy of Otolaryngology — Head & Neck Surgery
Current
New Mexico affiliations
NM Cancer Research Alliance, Class A participant (2024–); NM Society of Otolaryngology (2022–); NMSU Electrical & Computer Engineering Academy (2023–); UNM Comprehensive Cancer Center associate member
Past
Prior memberships
IEEE (2018–25); Society of Robotic Surgery (2017–24); American Thyroid Association (2014–24); International Society of Fluorescence Guided Surgery (2022–24); AMA alternate delegate from New Mexico (2023–25); Moores Cancer Center; UCSD CTRI

Committees & professional service

7 entries
2026–present
Lead Committee Member, Precision Oncology Alliance
Caris Life Sciences / University of New Mexico
2024–2026
New Mexico Medical Review Commission
Volunteer reviewer
2023–2026
UNM leadership & strategy committees
Clinician Advisory Group — leader, Surgery sub-group (2024–); HSC strategic workforce-development implementation teams; grant reviewer, Surgery Research Investigator Award
2021–2023
Scientific Review Committee, International Conference on Head & Neck Cancer
10th (2021) and 11th (2023) conferences; led proffered papers on functional outcomes, Montréal 2023
2021
Section chair, IEEE International Conference on Robotics and Automation
Scientific sections: motion planning for surgical robotics; surgical robotics
2018–2023
National committee service
AHNS Value & Quality of Care Service Committee (2018–21); AAO-HNS Head & Neck Surgery Education Committee consultant (2020–22); IEEE Robotics & Automation Society Technical Committee for Surgical Robotics (2018–23); AHNS webinar panelist (2021, 2022); core member, CHEER — Center for Health Equity, Education & Research, UCSD (2020–22)
2015–2022
UCSD academic committees
Medical School Electives Committee (2019–22); ACGME Program Evaluation Committee — faculty member (2018–22), resident member (2015–16); ACTRI grant review panels

Peer review

30+ journals since 2012

Ad hoc reviewer since 2012 for more than thirty journals and conferences across head & neck oncology, surgery, and robotics — including annual service to Head & Neck (2016–2026), plus Laryngoscope, Oral Oncology, Cancer, Clinical Cancer Research, Scientific Reports, PLOS ONE, Annals of Surgical Oncology, Journal of Robotic Surgery, Microsurgery, and IEEE robotics conferences (ICRA / IROS).